N-(6-OXO-5,6-DIHYDRO-PHENANTHRIDIN-2-YL)-N,N-DIMETHYLACETAMIDE HCL

Name	PJ34
Synonyms	PJ34 PJ-34 PJ34(free base) N,N-Dimethyl-2-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide N-(6-OXO-5,6-DIHYDRO-PHENANTHRIDIN-2-YL)-N,N-DIMETHYLACETAMIDE HCL Acetamide, N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)- N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide N-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)-N,N-DIMETHYLACETAMIDE HYDROCHLORIDE N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide PJ 34
CAS	344458-19-1
EINECS	604-604-1

Molecular Formula	C17H17N3O2
Molar Mass	295.34
Storage Condition	Sealed in dry,Store in freezer, under -20°C
Use	PJ34 is a potent and specific PARPl/2 inhibitor with IC50 of 110 nM and 86 nM, respectively.
In vitro study	PJ34 inhibits the PARP enzyme activity with an IC 50 of 110±1.9 nM. To compare the neuroprotective properties of other PARP inhibitors in PC12 cells, PJ34 is evaluated using by LDH assay. PJ34 treatment also significantly and concentration dependently attenuates cell death at a concentration ranging from 10 -7 to 10 -5 M.
In vivo study	To compare the potency and efficacy with other PARP inhibitors, PJ34 is evaluated at the doses of 3.2 and 10 mg/kg, respectively. PJ34 at the dose of 3.2 mg/kg significantly reduces cortical damage by 33%; however, 10 mg/kg dosing shows reversed effect (17% reduction). PJ34 (25 mg/kg) reduces the levels of TNF-α mRNA in ischemic animals by 70% and these values in treated mice do not differ from that of sham or naive animals. Treatment of ischemic mice with PJ34 reduces the level of E-selectin mRNA by 81% and that of ICAM-1 mRNA by 54%, compared to vehicle-treated ischemic mice.

biological activity	PJ34 is an effective specific PARPl/2 inhibitor with IC50 of 110 nM and 86 nM respectively.
target	PARP 110 nM (IC 50 ) PARP-2 86 nM (IC 50 ) PARP-1 110 nM (IC 50 )
in vitro study	PJ34 inhibits the PARP enzyme activity with an IC 50 of 110±1.9 nM. To compare the neuroprotective properties of other PARP inhibitors in PC12 cells, PJ34 is evaluated using by LDH say. PJ34 treatment also significantly and concentration dependently attenuates cell death at a concentration ranging from 10 -7 to 10 -5 m.
in vivo research	to compare the potency and efficacy with other PARP inhibitors, PJ34 is evaluated at the doses of 3.2 and 10 mg/kg, respectively. PJ34 at the dose of 3.2 mg/kg significantly reduces cortical damage by 33%; however, 10 mg/kg dosing shows reversed effect (17% reduction). PJ34 (25 mg/kg) reduces the levels of TNF-α mRNA in ischemic animals by 70% and these values in treated mice do not separate from that of sham or naive animals. Treatment of ischemic mice with PJ34 reduces the level of E-selectin mRNA by 81% and that of ICAM-1 mRNA by 54%, compared to vehicle-treated ischemic mice.

Last Update：2024-04-09 21:11:58

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CAS: 344458-19-1
Tel: 609-228-6898
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　　　　 tech@medchemexpress.com
Mobile: 609-228-6898

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Product Name: PJ34 Visit Supplier Webpage Request for quotation
CAS: 344458-19-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922

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CAS: 344458-19-1
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Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328

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N-(6-OXO-5,6-DIHYDRO-PHENANTHRIDIN-2-YL)-N,N-DIMETHYLACETAMIDE HCL Request for Quotation